Reaction Details
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Target
Gag-Pol polyprotein [588-1027,V767D]/[588-1147,V767D]
Ligand
BDBM27580
Substrate
poly(rA)/oligo(dT)
Meas. Tech.
Reverse Transcriptase Assay
Ki
300±n/a nM
Citation
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More Info.:
Target
Name:
Gag-Pol polyprotein [588-1027,V767D]/[588-1147,V767D]
Synonyms:
HIV-1 Reverse Transcriptase Mutant (V179D)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [588-1147,V767D]
Synonyms:
HIV-1 Reverse Transcriptase Mutant (V179D) Chain A | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
64501.36
Organism:
Human immunodeficiency virus type 1
Description:
P04585[588-1147,V767D]
Residue:
560
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIDIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVL
Component 2
Name:
Gag-Pol polyprotein [588-1027,V767D]
Synonyms:
HIV-1 Reverse Transcriptase Mutant (V179D) Chain B | POL_HV1H2 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
51352.08
Organism:
Human immunodeficiency virus type 1
Description:
P04585[588-1027,V767D]
Residue:
440
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIDIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETF
Inhibitor
Name:
BDBM27580
Synonyms:
8-[4-(3-chlorophenoxymethyl)phenyl]-8-ethyl-9-oxa-2-azatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaen-7-one | Pyrrolobenzoxazepinone (PBO), 5
Type:
Small organic molecule
Emp. Form.:
C27H22ClNO3
Mol. Mass.:
443.921
SMILES:
CCC1(Oc2ccccc2-n2cccc2C1=O)c1ccc(COc2cccc(Cl)c2)cc1
Substrate
Name:
poly(rA)/oligo(dT)
Synonyms:
n/a
Type:
RNA/DNA duplex
Mol. Mass.:
358.43
Organism:
n/a
Description:
[3H]-dTTP is co-substrate.
Residue:
3
Sequence:
NA