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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM393983
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
3.00±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM393983
Synonyms:
6-(2-aminopyridin-4- yl)-N-(trans-4- morpholin-4- ylcyclohexyl)quinazolin- 4-amine | US9969749, Example 1-74
Type:
Small organic molecule
Emp. Form.:
C23H28N6O
Mol. Mass.:
404.508
SMILES:
Nc1cc(ccn1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1 |r,wU:16.16,wD:19.23,(-2.7,8.67,;-1.93,7.34,;-2.7,6,;-1.93,4.67,;-.39,4.67,;.38,6,;-.39,7.34,;-2.7,3.33,;-4.24,3.33,;-5.01,2,;-4.24,.67,;-5.01,-.67,;-4.24,-2,;-2.7,-2,;-1.93,-.67,;-.39,-.67,;.38,-2,;1.92,-2,;2.69,-3.33,;1.92,-4.67,;.38,-4.67,;-.39,-3.33,;2.69,-6,;1.92,-7.34,;2.69,-8.67,;4.23,-8.67,;5.01,-7.34,;4.23,-6,;-2.7,.67,;-1.93,2,)|
Structure:
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