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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM396030
Substrate
n/a
Meas. Tech.
SHP2 Allosteric Inhibition Assay
IC50
16.0±n/a nM
Citation
 Chen, Z; Fortanet, JG; LaMarche, MJ; Sendzik, M; Tamez, Jr., V; Yu, B Compounds and compositions for inhibiting the activity of SHP2 US Patent  US10308660 Publication Date 6/4/2019 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM396030
Synonyms:
US10308660, Example 132
Type:
Small organic molecule
Emp. Form.:
C20H25Cl2N5O2
Mol. Mass.:
438.351
SMILES:
C[C@@H]1OCC2(CCN(CC2)c2nc(N)c(-c3cccc(Cl)c3Cl)c(=O)n2C)[C@@H]1N |r,wD:27.31,1.0,(6.18,5.9,;5.78,4.42,;6.55,3.08,;5.52,1.94,;4.12,2.57,;4.12,1.03,;2.78,.26,;1.45,1.03,;1.45,2.57,;2.78,3.34,;.11,.26,;-1.22,1.03,;-2.55,.26,;-3.89,1.03,;-2.55,-1.28,;-3.89,-2.05,;-5.22,-1.28,;-6.55,-2.05,;-6.55,-3.59,;-5.22,-4.36,;-5.22,-5.9,;-3.89,-3.59,;-2.55,-4.36,;-1.22,-2.05,;-1.22,-3.59,;.11,-1.28,;1.45,-2.05,;4.28,4.1,;3.19,5.19,)|
Structure:
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