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Target
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E]
Ligand
BDBM33262
Substrate
BDBM33263
Meas. Tech.
Protease Inhibition Assay
pH
8.5±n/a
Temperature
296.15±n/a K
Ki
1783000±113000 nM
Citation
 Ganesh, VK; Muller, N; Judge, K; Luan, CH; Padmanabhan, R; Murthy, KH Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases. Bioorg Med Chem 13:257-64 (2005) [PubMed]  Article 
Target
Name:
Genome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E]
Synonyms:
Dengue 2 NS2B(H):NS3 | Dengue Virus 2 (DENV2) NS2B-NS3 Protease
Type:
Cofactor/Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Genome polyprotein [1394-1440,K1405R,D1408E]
Synonyms:
Flavivirus non-structural protein NS2B | NS2B | POLG_DEN2N
Type:
Cofactor Domain
Mol. Mass.:
5197.48
Organism:
Dengue virus 2
Description:
P14340[1394-1440,K1405R,D1408E]
Residue:
47
Sequence:
ADLELERAADVRWEEQAEISGSSPILSITISEDGSMSIKNEEEEQTL
  
Component 2
Name:
Genome polyprotein [1066-1250,R1182K]
Synonyms:
Flavivirus NS3 serine protease | NS3 | POLG_DEN2T
Type:
Catalytic Domain
Mol. Mass.:
19925.90
Organism:
Dengue virus 2
Description:
n/a
Residue:
185
Sequence:
AGVLWDVPSPPPVGKAELEDGAYRIKQKGILGYSQIGAGVYKEGTFHTMWHVTRGAVLMHKGKRIEPSWADVKKDLISYGGGWKLEGEWKEGEEVQVLALEPGKNPRAVQTKPGLFKTNTGTIGAVSLDFSPGTSGSPIVDKKGKVVGLYGNGVVTRSGAYVSAIAQTEKSIEDNPEIEDDIFRK
  
Inhibitor
Name:
BDBM33262
Synonyms:
biguanidine, 3
Type:
Small organic molecule
Emp. Form.:
C8H16N8
Mol. Mass.:
224.2662
SMILES:
[#7]-[#6](-[#7])-[#7]-[#7]-c1ccc(-[#7]\[#7]=[#6](\[#7])-[#7])cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM33263
Synonyms:
AMC, 7-amido-4-methylcoumarin | Boc-Gly-Arg-Arg-AMC
Type:
fluorogenic peptide substrate
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: