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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43492
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
10±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43492
Synonyms:
1-(3,5-dichlorophenyl)-4-(3-pyridinylmethylideneamino)piperazine-2,5-dione | 1-(3,5-dichlorophenyl)-4-(3-pyridylmethyleneamino)piperazine-2,5-quinone | 1-(3,5-dichlorophenyl)-4-(pyridin-3-ylmethylideneamino)piperazine-2,5-dione | 1-(3,5-dichlorophenyl)-4-[(pyridin-3-ylmethylene)amino]tetrahydropyrazine-2,5-dione | 1-[3,5-bis(chloranyl)phenyl]-4-(pyridin-3-ylmethylideneamino)piperazine-2,5-dione | MLS000861890 | SMR000460674 | cid_2733030
Type:
Small organic molecule
Emp. Form.:
C16H12Cl2N4O2
Mol. Mass.:
363.198
SMILES:
Clc1cc(Cl)cc(c1)N1CC(=O)N(CC1=O)N=Cc1cccnc1 |w:16.17|
Structure:
Search PDB for entries with ligand similarity: