Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43518
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
20310±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43518
Synonyms:
2-[(E)-1-(benzenesulfonyl)-2-(3-methylphenyl)ethenyl]-1H-benzimidazole | 2-[(E)-1-besyl-2-(m-tolyl)vinyl]-1H-benzimidazole | 2-[(E)-2-(3-methylphenyl)-1-(phenylsulfonyl)ethenyl]-1H-benzimidazole | MLS000391257 | SMR000260294 | cid_6265504
Type:
Small organic molecule
Emp. Form.:
C22H18N2O2S
Mol. Mass.:
374.456
SMILES:
Cc1cccc(\C=C(/c2nc3ccccc3[nH]2)S(=O)(=O)c2ccccc2)c1
Structure:
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