Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM48957
Substrate
n/a
Meas. Tech.
Allosteric Modulators of D1 Receptors: Dose-dependent Assay
EC50
0.00135±n/a nM
Citation
 PubChem, PC Allosteric Modulators of D1 Receptors: Dose-dependent Assay PubChem Bioassay (2007)[AID] 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Human
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM48957
Synonyms:
(5Z)-2-(1-azepanyl)-5-(7-bromo-5-methyl-2-oxo-1H-indol-3-ylidene)-4-thiazolone | (5Z)-2-(azepan-1-yl)-5-(7-bromanyl-5-methyl-2-oxidanylidene-1H-indol-3-ylidene)-1,3-thiazol-4-one | (5Z)-2-(azepan-1-yl)-5-(7-bromo-2-keto-5-methyl-indolin-3-ylidene)-2-thiazolin-4-one | (5Z)-2-(azepan-1-yl)-5-(7-bromo-5-methyl-2-oxo-1H-indol-3-ylidene)-1,3-thiazol-4-one | 3-[2-(1-azepanyl)-4-oxo-1,3-thiazol-5(4H)-ylidene]-7-bromo-5-methyl-1,3-dihydro-2H-indol-2-one | MLS000050455 | SMR000076359 | cid_5739634
Type:
Small organic molecule
Emp. Form.:
C18H18BrN3O2S
Mol. Mass.:
420.323
SMILES:
Cc1cc2\C(C(=O)Nc2c(Br)c1)=C1\SC(=NC1=O)N1CCCCCC1 |c:16|
Structure:
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