Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM51770
Substrate
n/a
Meas. Tech.
Fluorescent assay for identification of compounds that inhibit VHR1
IC50
2030±n/a nM
Citation
 PubChem, PC Fluorescent assay for identification of compounds that inhibit VHR1 PubChem Bioassay (2009)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM51770
Synonyms:
(4-amino-3-methyl-5-thieno[2,3-c]isothiazolyl)-(4-fluorophenyl)methanone | (4-amino-3-methyl-thien[2,3-c]isothiazol-5-yl)-(4-fluorophenyl)methanone | (4-amino-3-methylthieno[2,3-c][1,2]thiazol-5-yl)-(4-fluorophenyl)methanone | (4-amino-3-methylthieno[2,3-c]isothiazol-5-yl)(4-fluorophenyl)methanone | (4-azanyl-3-methyl-thieno[2,3-c][1,2]thiazol-5-yl)-(4-fluorophenyl)methanone | MLS000540418 | SMR000125676 | cid_1484492
Type:
Small organic molecule
Emp. Form.:
C13H9FN2OS2
Mol. Mass.:
292.352
SMILES:
Cc1snc2sc(C(=O)c3ccc(F)cc3)c(N)c12
Structure:
Search PDB for entries with ligand similarity: