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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM53472
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
4.1e+3±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
UCH-L1 | UCHL1_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) | Ubiquitin thioesterase L1 | Uchl1
Type:
Protein
Mol. Mass.:
24830.93
Organism:
Mus musculus (Mouse)
Description:
Q9R0P9
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM53472
Synonyms:
2-(2,6-Dichloro-phenyl)-2,3-dihydro-1H-perimidine | 2-(2,6-dichlorophenyl)-2,3-dihydro-1H-perimidine | 2-[2,6-bis(chloranyl)phenyl]-2,3-dihydro-1H-perimidine | MLS001204520 | O-acyl oxime isatin derivative, 54 | SMR000515760 | cid_727019
Type:
Small organic molecule
Emp. Form.:
C17H12Cl2N2
Mol. Mass.:
315.197
SMILES:
Clc1cccc(Cl)c1C1Nc2cccc3cccc(N1)c23
Structure:
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