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Target
SUMO-conjugating enzyme UBC9
Ligand
BDBM61248
Substrate
n/a
Meas. Tech.
AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation
IC50
7430±n/a nM
Citation
 PubChem, PC AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation PubChem Bioassay (2010)[AID] 
Target
Name:
SUMO-conjugating enzyme UBC9
Synonyms:
UBC9 | UBC9_HUMAN | UBCE9 | UBE2I | ubiquitin-conjugating enzyme E2I
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18011.66
Organism:
Homo sapiens (Human)
Description:
gi_4507785
Residue:
158
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
  
Inhibitor
Name:
BDBM61248
Synonyms:
2-(2-Cyclopropyl-quinazolin-4-ylsulfanyl)-N-(4-diethylamino-3-methyl-phenyl)-acetamide | 2-(2-cyclopropylquinazolin-4-yl)sulfanyl-N-[4-(diethylamino)-3-methyl-phenyl]ethanamide | 2-(2-cyclopropylquinazolin-4-yl)sulfanyl-N-[4-(diethylamino)-3-methylphenyl]acetamide | 2-[(2-cyclopropyl-4-quinazolinyl)thio]-N-[4-(diethylamino)-3-methylphenyl]acetamide | 2-[(2-cyclopropylquinazolin-4-yl)thio]-N-[4-(diethylamino)-3-methyl-phenyl]acetamide | MLS001221870 | SMR000600261 | cid_1435145
Type:
Small organic molecule
Emp. Form.:
C24H28N4OS
Mol. Mass.:
420.57
SMILES:
CCN(CC)c1ccc(NC(=O)CSc2nc(nc3ccccc23)C2CC2)cc1C
Structure:
Search PDB for entries with ligand similarity: