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Target
Streptokinase A
Ligand
BDBM53725
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
150000±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM53725
Synonyms:
MLS000035506 | N-[(5Z)-5-(4,5-dimethoxy-2-nitro-benzylidene)-4-keto-2-thiazolin-2-yl]benzenesulfonamide | N-[(5Z)-5-[(4,5-dimethoxy-2-nitro-phenyl)methylidene]-4-oxidanylidene-1,3-thiazol-2-yl]benzenesulfonamide | N-[(5Z)-5-[(4,5-dimethoxy-2-nitrophenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]benzenesulfonamide | N-[(5Z)-5-[(4,5-dimethoxy-2-nitrophenyl)methylidene]-4-oxo-2-thiazolyl]benzenesulfonamide | N-[5-(4,5-Dimethoxy-2-nitro-benzylidene)-4-oxo-thiazolidin-2-ylidene]-benzenesulfonamide | SMR000123103 | cid_1912687
Type:
Small organic molecule
Emp. Form.:
C18H15N3O7S2
Mol. Mass.:
449.458
SMILES:
COc1cc(\C=C2/SC(NS(=O)(=O)c3ccccc3)=NC2=O)c(cc1OC)[N+]([O-])=O |c:19|
Structure:
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