Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM57009
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction revised
IC50
>20000±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction revised PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM57009
Synonyms:
MLS000066779 | N-(1-benzyl-1H-benzimidazol-2-yl)-2-furamide | N-(1-benzylbenzimidazol-2-yl)-2-furamide | N-(1-benzylbenzimidazol-2-yl)furan-2-carboxamide | N-[1-(phenylmethyl)-2-benzimidazolyl]-2-furancarboxamide | N-[1-(phenylmethyl)benzimidazol-2-yl]furan-2-carboxamide | SMR000070010 | cid_867564
Type:
Small organic molecule
Emp. Form.:
C19H15N3O2
Mol. Mass.:
317.3413
SMILES:
O=C(Nc1nc2ccccc2n1Cc1ccccc1)c1ccco1
Structure:
Search PDB for entries with ligand similarity: