Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM44614
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM44614
Synonyms:
2-[3-(2-furanylmethyl)-4-imino-6,6-dimethyl-2-oxo-5,8-dihydropyrano[2,3]thieno[2,4-b]pyrimidin-1-yl]-N-(3-methylphenyl)acetamide | 2-[3-(2-furfuryl)-4-imino-2-keto-6,6-dimethyl-5,8-dihydropyrano[2,3]thieno[2,4-b]pyrimidin-1-yl]-N-(m-tolyl)acetamide | 2-[3-(furan-2-ylmethyl)-4-imino-6,6-dimethyl-2-oxo-5,8-dihydropyrano[2,3]thieno[2,4-b]pyrimidin-1-yl]-N-(3-methylphenyl)acetamide | 2-[4-azanylidene-3-(furan-2-ylmethyl)-6,6-dimethyl-2-oxidanylidene-5,8-dihydropyrano[2,3]thieno[2,4-b]pyrimidin-1-yl]-N-(3-methylphenyl)ethanamide | MLS000084018 | SMR000046848 | cid_665615
Type:
Small organic molecule
Emp. Form.:
C25H26N4O4S
Mol. Mass.:
478.563
SMILES:
Cc1cccc(NC(=O)Cn2c3sc4COC(C)(C)Cc4c3c(=N)n(Cc3ccco3)c2=O)c1
Structure:
Search PDB for entries with ligand similarity: