Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM54219
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
11782.5±1515 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54219
Synonyms:
4-methyl-N-[2-[2-(tosylamino)phenyl]phenyl]benzenesulfonamide | 4-methyl-N-[2-[2-[(4-methylphenyl)sulfonylamino]phenyl]phenyl]benzenesulfonamide | MLS000572914 | N,N'-2,2'-biphenyldiylbis(4-methylbenzenesulfonamide) | SMR000195221 | cid_1010988
Type:
Small organic molecule
Emp. Form.:
C26H24N2O4S2
Mol. Mass.:
492.61
SMILES:
Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1-c1ccccc1NS(=O)(=O)c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: