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Target
Caspase-3
Ligand
BDBM46760
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
36200±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM46760
Synonyms:
4-[(4-fluorophenyl)carbamoylamino]benzoic acid ethyl ester | 4-[[(4-fluoroanilino)-oxomethyl]amino]benzoic acid ethyl ester | MLS000570039 | SMR000150113 | US11339122, Compound 5b | cid_306328 | ethyl 4-[(4-fluorophenyl)carbamoylamino]benzoate
Type:
Small organic molecule
Emp. Form.:
C16H15FN2O3
Mol. Mass.:
302.3003
SMILES:
CCOC(=O)c1ccc(NC(=O)Nc2ccc(F)cc2)cc1
Structure:
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