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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM38935
Substrate
n/a
Meas. Tech.
Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1)
IC50
48103±n/a nM
Citation
 PubChem, PC Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) PubChem Bioassay (2011)[AID] 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Human
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM38935
Synonyms:
2-(1-ethyl-2-methyl-5-benzimidazolyl)-5H-[1,2,4]triazolo[5,1-a]isoindole | 2-(1-ethyl-2-methyl-benzimidazol-5-yl)-5H-[1,2,4]triazol[5,1-a]isoindole | 2-(1-ethyl-2-methyl-benzimidazol-5-yl)-5H-[1,2,4]triazolo[5,1-a]isoindole | 2-(1-ethyl-2-methylbenzimidazol-5-yl)-5H-[1,2,4]triazolo[5,1-a]isoindole | MLS000054270 | SMR000066223 | cid_2347892
Type:
Small organic molecule
Emp. Form.:
C19H17N5
Mol. Mass.:
315.3718
SMILES:
CCn1c(C)nc2cc(ccc12)-c1nc2-c3ccccc3Cn2n1
Structure:
Search PDB for entries with ligand similarity: