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Target
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM54759
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
44000±n/a nM
Comments
extracted
Citation
 PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] 
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
  
Inhibitor
Name:
BDBM54759
Synonyms:
1-(4-chloranyl-2,5-dimethoxy-phenyl)pyrrole-2,5-dione | 1-(4-chloro-2,5-dimethoxy-phenyl)-3-pyrroline-2,5-quinone | 1-(4-chloro-2,5-dimethoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione | 1-(4-chloro-2,5-dimethoxyphenyl)pyrrole-2,5-dione | MLS000833773 | SMR000457494 | cid_2803479
Type:
Small organic molecule
Emp. Form.:
C12H10ClNO4
Mol. Mass.:
267.665
SMILES:
COc1cc(N2C(=O)C=CC2=O)c(OC)cc1Cl |c:8|
Structure:
Search PDB for entries with ligand similarity: