Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM61585
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
4620±259 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM61585
Synonyms:
(4S)-1-benzyl-6-methyl-4-phenyl-2-[2-(3-pyridyl)ethylamino]-4H-pyrimidine-5-carboxylic acid methyl ester | (4S)-6-methyl-4-phenyl-1-(phenylmethyl)-2-[2-(3-pyridinyl)ethylamino]-4H-pyrimidine-5-carboxylic acid methyl ester | MLS000829873 | SMR000672007 | cid_24789241 | methyl (4S)-1-benzyl-6-methyl-4-phenyl-2-(2-pyridin-3-ylethylamino)-4H-pyrimidine-5-carboxylate | methyl (4S)-6-methyl-4-phenyl-1-(phenylmethyl)-2-(2-pyridin-3-ylethylamino)-4H-pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C27H28N4O2
Mol. Mass.:
440.5368
SMILES:
COC(=O)C1=C(C)N(Cc2ccccc2)C(NCCc2cccnc2)=N[C@H]1c1ccccc1 |c:4,26|
Structure:
