Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80542
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
892±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80542
Synonyms:
1-Methyl-2-((E)-2-quinolin-6-yl-vinyl)-pyridinium | 6-[(E)-2-(1-methyl-2-pyridin-1-iumyl)ethenyl]quinoline;iodide | 6-[(E)-2-(1-methylpyridin-1-ium-2-yl)ethenyl]quinoline;iodide | 6-[(E)-2-(1-methylpyridin-1-ium-2-yl)vinyl]quinoline;iodide | MLS001208265 | SMR000504367 | cid_24746842
Type:
Small organic molecule
Emp. Form.:
C17H15N2
Mol. Mass.:
247.3139
SMILES:
C[n+]1ccccc1\C=C\c1ccc2ncccc2c1
Structure:
