Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50137675
Substrate
n/a
Meas. Tech.
Enzyme Inhbition Assay
pH
7.5±0
Temperature
293.15±0 K
Ki
16±0.0 nM
Citation
 Winum, JY; Montero, JL; Vullo, D; Supuran, CT Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI. Chem Biol Drug Des 74:636-9 (2009) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Human
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50137675
Synonyms:
4-(3,4,5-Trihydroxy-tetrahydro-pyran-2-ylamino)-benzenesulfonamide | CHEMBL308495 | N-(p-sulfamoylphenyl)-alpha-glycopyranosylamine, 4 | N-(p-sulfamoylphenyl)-alpha-glycopyranosylamine, 5 | N-(p-sulfamoylphenyl)-alpha-glycopyranosylamine, 6
Type:
Small organic molecule
Emp. Form.:
C11H16N2O6S
Mol. Mass.:
304.32
SMILES:
NS(=O)(=O)c1ccc(NC2OCC(O)C(O)C2O)cc1
Structure:
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