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Target
Beta-lactamase
Ligand
BDBM57378
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA)
IC50
11892±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) PubChem Bioassay (2011)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM57378
Synonyms:
5-(4-chlorophenyl)sulfinyl-N-phenyl-1,2,3-thiadiazole-4-carboxamide | 5-(4-chlorophenyl)sulfinyl-N-phenyl-4-thiadiazolecarboxamide | 5-(4-chlorophenyl)sulfinyl-N-phenyl-thiadiazole-4-carboxamide | 5-(4-chlorophenyl)sulfinyl-N-phenylthiadiazole-4-carboxamide | 5-[(4-chlorophenyl)sulfinyl]-N-phenyl-1,2,3-thiadiazole-4-carboxamide | MLS000326106 | SMR000170268 | cid_1486982
Type:
Small organic molecule
Emp. Form.:
C15H10ClN3O2S2
Mol. Mass.:
363.842
SMILES:
Clc1ccc(cc1)S(=O)c1snnc1C(=O)Nc1ccccc1
Structure:
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