Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM78178
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM78178
Synonyms:
3-[2-(3-Hydroxy-phenylamino)-thiazol-4-yl]-6-methoxy-chromen-2-one | 3-[2-(3-hydroxyanilino)-1,3-thiazol-4-yl]-6-methoxychromen-2-one | 3-[2-(3-hydroxyanilino)-4-thiazolyl]-6-methoxy-1-benzopyran-2-one | 3-[2-(3-hydroxyanilino)thiazol-4-yl]-6-methoxy-coumarin | 3-[2-[(3-hydroxyphenyl)amino]-1,3-thiazol-4-yl]-6-methoxy-chromen-2-one | MLS000548677 | SMR000172285 | cid_1077600
Type:
Small organic molecule
Emp. Form.:
C19H14N2O4S
Mol. Mass.:
366.39
SMILES:
COc1ccc2oc(=O)c(cc2c1)-c1csc(Nc2cccc(O)c2)n1
Structure:
Search PDB for entries with ligand similarity: