Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50252458
Substrate
n/a
Meas. Tech.
ChEBML_1684948
IC50
210±n/a nM
Citation
 Umei, K; Nishigaya, Y; Tatani, K; Kohno, Y; Tanaka, N; Seto, S Identification of novel 1,2,3,6-tetrahydropyridyl-substituted benzo[d]thiazoles: Lead generation and optimization toward potent and orally active EP Bioorg Med Chem 25:3406-3430 (2017) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_RAT | Prostanoid EP1 receptor | Ptger1
Type:
Enzyme
Mol. Mass.:
43080.10
Organism:
Rattus norvegicus (Rat)
Description:
P70597
Residue:
405
Sequence:
MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
  
Inhibitor
Name:
BDBM50252458
Synonyms:
CHEMBL4088446
Type:
Small organic molecule
Emp. Form.:
C20H23N5O2S
Mol. Mass.:
397.494
SMILES:
CN(C)c1cc(Cn2nc(cc2C)C(O)=O)c2nc(sc2c1)N1CCC=CC1 |c:28|
Structure:
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