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Target
Histone deacetylase 8
Ligand
BDBM50259808
Substrate
n/a
Meas. Tech.
ChEBML_1691855
IC50
390±n/a nM
Citation
 Lee, HY; Lee, JF; Kumar, S; Wu, YW; HuangFu, WC; Lai, MJ; Li, YH; Huang, HL; Kuo, FC; Hsiao, CJ; Cheng, CC; Yang, CR; Liou, JP 3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity. Eur J Med Chem 125:1268-1278 (2017) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Human
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50259808
Synonyms:
CHEMBL4093691
Type:
Small organic molecule
Emp. Form.:
C27H26N2O7
Mol. Mass.:
490.5045
SMILES:
COc1ccc2c(cn(Cc3ccc(cc3)C(=O)NO)c2c1)C(=O)c1cc(OC)c(OC)c(OC)c1
Structure:
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