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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM50263394
Substrate
n/a
Meas. Tech.
ChEBML_1697924
Ki
49±n/a nM
Citation
 Pomplun, S; Sippel, C; Hähle, A; Tay, D; Shima, K; Klages, A; Ünal, CM; Rieß, B; Toh, HT; Hansen, G; Yoon, HS; Bracher, A; Preiser, P; Rupp, J; Steinert, M; Hausch, F Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins. J Med Chem 61:3660-3673 (2018) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM50263394
Synonyms:
CHEMBL4069155
Type:
Small organic molecule
Emp. Form.:
C18H21Cl2FN2O3S
Mol. Mass.:
435.34
SMILES:
[H][C@]12CCC[C@]([H])(N1S(=O)(=O)c1cc(Cl)cc(Cl)c1)C(=O)N(CCF)C[C@H]2C=C |r,TLB:27:26:7:3.2.4,20:19:7:3.2.4,THB:22:21:7:3.2.4|
Structure:
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