Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50266899
Substrate
n/a
Meas. Tech.
ChEMBL_1701465 (CHEMBL4052447)
Ki
28000±n/a nM
Citation
 Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem 60:4234-4244 (2017) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50266899
Synonyms:
CHEMBL4102063
Type:
Small organic molecule
Emp. Form.:
C35H28Cl2FN5O2
Mol. Mass.:
640.534
SMILES:
Fc1ccc(cc1)-c1ncn(Cc2ccc(Cl)cc2)c1-c1c([nH]c2cc(Cl)ccc12)C(=O)Nc1ccc(cc1)N1CCOCC1 |(28.53,-12.05,;26.99,-12.05,;26.22,-10.71,;24.68,-10.71,;23.91,-12.05,;24.68,-13.39,;26.22,-13.39,;22.37,-12.05,;21.47,-10.81,;20.01,-11.28,;20.01,-12.82,;18.76,-13.73,;17.35,-13.1,;16.1,-14.01,;14.7,-13.38,;14.54,-11.85,;13.13,-11.22,;15.79,-10.95,;17.19,-11.57,;21.47,-13.29,;21.95,-14.77,;21.04,-16.01,;21.95,-17.26,;23.41,-16.78,;24.74,-17.55,;26.08,-16.78,;27.42,-17.55,;26.08,-15.24,;24.74,-14.47,;23.41,-15.24,;19.5,-16.01,;18.73,-14.67,;18.73,-17.34,;17.19,-17.34,;16.42,-18.68,;14.88,-18.68,;14.12,-17.34,;14.88,-16.01,;16.42,-16.01,;12.58,-17.34,;11.81,-18.68,;10.27,-18.68,;9.5,-17.34,;10.27,-16.01,;11.81,-16.01,)|
Structure:
Search PDB for entries with ligand similarity: