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Target
Stearoyl-CoA desaturase
Ligand
BDBM50267930
Substrate
n/a
Meas. Tech.
ChEMBL_1704128 (CHEMBL4055361)
IC50
2.3±n/a nM
Citation
 Imamura, K; Tomita, N; Kawakita, Y; Ito, Y; Ono, K; Nii, N; Miyazaki, T; Yonemori, K; Tawada, M; Sumi, H; Satoh, Y; Yamamoto, Y; Miyahisa, I; Sasaki, M; Satomi, Y; Hirayama, M; Nishigaki, R; Maezaki, H Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents. Bioorg Med Chem 25:3768-3779 (2017) [PubMed]  Article 
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Homo sapiens (Human)
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
  
Inhibitor
Name:
BDBM50267930
Synonyms:
CHEMBL4104190
Type:
Small organic molecule
Emp. Form.:
C20H17F6N5O2
Mol. Mass.:
473.3717
SMILES:
OCc1noc(n1)-c1ccc(nn1)N1CCC(CC1)(c1ccc(cc1)C(F)(F)F)C(F)(F)F
Structure:
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