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Target
Signal transducer and activator of transcription 5A
Ligand
BDBM50118228
Substrate
n/a
Meas. Tech.
ChEMBL_1704633 (CHEMBL4055866)
IC50
8800±n/a nM
Citation
 Berg, A; Berg, T A small-molecule screen identifies the antitrypanosomal agent suramin and analogues NF023 and NF449 as inhibitors of STAT5a/b. Bioorg Med Chem Lett 27:3349-3352 (2017) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 5A
Synonyms:
STA5A_HUMAN | STAT5 | STAT5A | Signal transducer and activator of transcription 5A | Transcription factor STAT5a (STAT5a)
Type:
Protein
Mol. Mass.:
90643.89
Organism:
Human
Description:
n/a
Residue:
794
Sequence:
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS
  
Inhibitor
Name:
BDBM50118228
Synonyms:
5,7-Disulfo-4-(3-{3-[3-(4,6,8-trisulfo-naphthalen-1-ylcarbamoyl)-phenyl]-ureido}-benzoylamino)-naphthalene-1-sulfonic acid anion;hexasodium salt | CHEMBL216504 | Urea derivative
Type:
Small organic molecule
Emp. Form.:
C35H20N4O21S6
Mol. Mass.:
1024.941
SMILES:
[O-]S(=O)(=O)c1cc(c2c(NC(=O)c3cccc(NC(=O)Nc4cccc(c4)C(=O)Nc4ccc(c5cc(cc(c45)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c3)ccc(c2c1)S([O-])(=O)=O)S([O-])(=O)=O
Structure:
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