Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM50270470
Substrate
n/a
Meas. Tech.
ChEMBL_1708182 (CHEMBL4059415)
Ki
100±n/a nM
Citation
 Le Hiress, M; Akagah, B; Bernadat, G; Tu, L; Thuillet, R; Huertas, A; Phan, C; Fadel, E; Simonneau, G; Humbert, M; Jalce, G; Guignabert, C Design, Synthesis, and Biological Activity of New N-(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension. J Med Chem 61:2725-2736 (2018) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50270470
Synonyms:
CHEMBL4094592
Type:
Small organic molecule
Emp. Form.:
C15H13NO2S
Mol. Mass.:
271.334
SMILES:
Cc1ccc2oc(=S)n(Cc3cccc(O)c3)c2c1
Structure:
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