Target
Cytochrome P450 2D6
Ligand
BDBM50416875
Substrate
n/a
Meas. Tech.
ChEMBL_1712616 (CHEMBL4122665)
IC50
<100±n/a nM
Citation
 Miyazaki, HIkeda, YSakurai, OMiyake, TTsubota, ROkabe, JKuroda, MHisada, YYanagida, TYoneda, HTsukumo, YTokunaga, SKawata, TOhashi, RFukuda, HKojima, KKannami, AKifuji, TSato, NIdei, AIguchi, TSakairi, TMoritani, Y Discovery of evocalcet, a next-generation calcium-sensing receptor agonist for the treatment of hyperparathyroidism. Bioorg Med Chem Lett 28:2055-2060 (2018) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50416875
Synonyms:
AMG-073 | AMG073 HCL | CINACALCET | CINACALCET HYDROCHLORIDE | US9487494, Cinacalcet
Type:
Small organic molecule
Emp. Form.:
C22H22F3N
Mol. Mass.:
357.412
SMILES:
C[C@@H](NCCCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: