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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM50286623
Substrate
n/a
Meas. Tech.
ChEMBL_1729074 (CHEMBL4144352)
IC50
20±n/a nM
Citation
 Chen, W; Dong, G; Wu, Y; Zhang, W; Miao, C; Sheng, C Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery. ACS Med Chem Lett 9:34-38 (2018) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM50286623
Synonyms:
CHEMBL4163345
Type:
Small organic molecule
Emp. Form.:
C21H34N6O3S
Mol. Mass.:
450.598
SMILES:
CC(C)CCN(CCCCCC(=O)NO)c1ncc(s1)C(=O)NCCCn1ccnc1
Structure:
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