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Target
Aurora kinase B
Ligand
BDBM50292249
Substrate
n/a
Meas. Tech.
ChEMBL_1731712 (CHEMBL4147248)
IC50
102±n/a nM
Citation
 Long, L; Luo, Y; Hou, ZJ; Ma, HJ; Long, ZJ; Tu, ZC; Huang, LJ; Liu, Q; Lu, G Synthesis and biological evaluation of aurora kinases inhibitors based on N-trisubstituted pyrimidine scaffold. Eur J Med Chem 145:805-812 (2018) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50292249
Synonyms:
CHEMBL4168905
Type:
Small organic molecule
Emp. Form.:
C19H23FN8
Mol. Mass.:
382.4379
SMILES:
CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Nc2cccc(F)c2)n1
Structure:
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