Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50310711
Substrate
n/a
Meas. Tech.
ChEMBL_1733122 (CHEMBL4148658)
Ki
14±n/a nM
Citation
 Sun, YT; Wang, GF; Yang, YQ; Jin, F; Wang, Y; Xie, XY; Mach, RH; Huang, YS Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands. Eur J Med Chem 147:227-237 (2018) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM50310711
Synonyms:
CHEMBL4161270
Type:
Small organic molecule
Emp. Form.:
C24H29N3O5
Mol. Mass.:
439.5042
SMILES:
COc1cc2CCN(CCCn3cnc4cc(OC)c(OC)cc4c3=O)Cc2cc1OC
Structure:
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