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Target
Prostaglandin E synthase
Ligand
BDBM50371232
Substrate
n/a
Meas. Tech.
ChEMBL_1736785 (CHEMBL4152535)
IC50
5000±n/a nM
Citation
 Khan, H; Rengasamy, KRR; Pervaiz, A; Nabavi, SM; Atanasov, AG; Kamal, MA Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation. Eur J Med Chem 153:2-28 (2018) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50371232
Synonyms:
CARNOSIC ACID
Type:
Small organic molecule
Emp. Form.:
C20H28O4
Mol. Mass.:
332.4339
SMILES:
CC(C)c1cc2CC[C@H]3C(C)(C)CCC[C@]3(C(O)=O)c2c(O)c1O |r|
Structure:
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