Reaction Details Report a problem with these data
Target
Thromboxane A2 receptor
Ligand
BDBM50228336
Substrate
n/a
Meas. Tech.
ChEMBL_209433 (CHEMBL814290)
IC50
2.1±n/a nM
Comments
Zero 12/22/2021
Citation
 Shiraishi, M; Kato, K; Terao, S; Ashida, Y; Terashita, Z; Kito, G Quinones. 4. Novel eicosanoid antagonists: synthesis and pharmacological evaluation. J Med Chem 32:2214-21 (1989) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50228336
Synonyms:
CHEMBL71879
Type:
Small organic molecule
Emp. Form.:
C22H26O4
Mol. Mass.:
354.4394
SMILES:
[H][C@](CCCCCC(O)=O)(C1=C(C)C(=O)C(C)=C(C)C1=O)c1ccccc1 |c:10,t:16|
Structure:
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