Reaction Details Report a problem with these data
Target
Solute carrier family 15 member 1
Ligand
BDBM50449800
Substrate
n/a
Meas. Tech.
ChEMBL_1740626 (CHEMBL4156376)
Ki
320000±n/a nM
Citation
 Foley, DW; Pathak, RB; Phillips, TR; Wilson, GL; Bailey, PD; Pieri, M; Senan, A; Meredith, D Thiodipeptides targeting the intestinal oligopeptide transporter as a general approach to improving oral drug delivery. Eur J Med Chem 156:180-189 (2018) [PubMed]  Article 
Target
Name:
Solute carrier family 15 member 1
Synonyms:
Intestinal H(+)/peptide cotransporter | Oligopeptide transporter, small intestine isoform | PEPT1 | Peptide transporter 1 | S15A1_RABIT | SLC15A1 | Solute carrier family 15 member 1
Type:
PROTEIN
Mol. Mass.:
78931.16
Organism:
Rabbit
Description:
ChEMBL_109684
Residue:
707
Sequence:
MGMSKSLSCFGYPLSIFFIVVNEFCERFSYYGMRALLILYFRNFIGWDDNLSTVIYHTFVALCYLTPILGALIADAWLGKFKTIVWLSIVYTIGQAVTSLSSVNELTDNNHDGTPDSLPVHVAVCMIGLLLIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTIITPMVRVQQCGIHVKQACYPLAFGIPAILMAVSLIVFIIGSGMYKKFKPQGNILSKVVKCICFAIKNRFRHRSKQFPKRAHWLDWAKEKYDERLIAQIKMVTRVLFLYIPLPMFWALFDQQGSRWTLQATTMSGRIGILEIQPDQMQTVNTILIIILVPIMDAVVYPLIAKCGLNFTSLKKMTIGMFLASMAFVAAAILQVEIDKTLPVFPKANEVQIKVLNVGSENMIISLPGQTVTLNQMSQTNEFMTFNEDTLTSINITSGSQVTMITPSLEAGQRHTLLVWAPNNYRVVNDGLTQKSDKGENGIRFVNTYSQPINVTMSGKVYEHIASYNASEYQFFTSGVKGFTVSSAGISEQCRRDFESPYLEFGSAYTYLITSQATGCPQVTEFEDIPPNTMNMAWQIPQYFLITSGEVVFSITGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGQINKQWAEYILFAALLLVVCVIFAIMARFYTYVNPAEIEAQFEEDEKKKNPEKNDLYPSLAPVSQTQM
  
Inhibitor
Name:
BDBM50449800
Synonyms:
CHEMBL4171174
Type:
Small organic molecule
Emp. Form.:
C12H17N3OS
Mol. Mass.:
251.348
SMILES:
C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=S |r|
Structure:
Search PDB for entries with ligand similarity: