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Target
Listeriolysin regulatory protein
Ligand
BDBM50453143
Substrate
n/a
Meas. Tech.
ChEMBL_1749230 (CHEMBL4183740)
IC50
65600±n/a nM
Citation
 Kulén, M; Lindgren, M; Hansen, S; Cairns, AG; Grundström, C; Begum, A; van der Lingen, I; Brännström, K; Hall, M; Sauer, UH; Johansson, J; Sauer-Eriksson, AE; Almqvist, F Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes. J Med Chem 61:4165-4175 (2018) [PubMed]  Article 
Target
Name:
Listeriolysin regulatory protein
Synonyms:
Listeriolysin regulatory protein | PRFA_LISMO | prfA
Type:
PROTEIN
Mol. Mass.:
27304.64
Organism:
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Description:
ChEMBL_117820
Residue:
237
Sequence:
MNAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSGIAHSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN
  
Inhibitor
Name:
BDBM50453143
Synonyms:
CHEMBL4215684
Type:
Small organic molecule
Emp. Form.:
C20H17NO4S
Mol. Mass.:
367.418
SMILES:
COc1c2SCC(C(O)=O)n2c(=O)cc1Cc1cccc2ccccc12
Structure:
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