Reaction Details Report a problem with these data
Target
Glutathione S-transferase omega-1
Ligand
BDBM50277889
Substrate
n/a
Meas. Tech.
ChEMBL_1764013 (CHEMBL4199260)
IC50
150±n/a nM
Citation
 Xie, Y; Dahlin, JL; Oakley, AJ; Casarotto, MG; Board, PG; Baell, JB Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example. J Med Chem 61:7448-7470 (2018) [PubMed]  Article 
Target
Name:
Glutathione S-transferase omega-1
Synonyms:
GSTO 1-1 | GSTO1 | GSTO1_HUMAN | GSTTLP28 | Glutathione S-transferase omega-1 | Glutathione transferase omega 1 | glutathione S-transferase omega-1 isoform 1
Type:
PROTEIN
Mol. Mass.:
27565.54
Organism:
Homo sapiens (Human)
Description:
EBI_11172
Residue:
241
Sequence:
MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKPEWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELFSKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPWFERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYGL
  
Inhibitor
Name:
BDBM50277889
Synonyms:
CARFILZOMIB | CHEMBL451887
Type:
Small organic molecule
Emp. Form.:
C40H57N5O7
Mol. Mass.:
719.9099
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Structure:
Search PDB for entries with ligand similarity: