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Target
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Ligand
BDBM320642
Substrate
n/a
Meas. Tech.
ChEMBL_1765296 (CHEMBL4200543)
IC50
899±n/a nM
Citation
 Stachel, SJ; Berger, R; Nomland, AB; Ginnetti, AT; Paone, DV; Wang, D; Puri, V; Lange, H; Drott, J; Lu, J; Marcus, J; Dwyer, MP; Suon, S; Uslaner, JM; Smith, SM Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor. ACS Med Chem Lett 9:815-820 (2018) [PubMed]  Article 
Target
Name:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Synonyms:
3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A)
Type:
Protein
Mol. Mass.:
68488.40
Organism:
Homo sapiens (Human)
Description:
O76083
Residue:
593
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
  
Inhibitor
Name:
BDBM320642
Synonyms:
(S)-3-(Fluoromethyl)-6-hydroxy-1- (1-(4- (pentafluorolhio)phenyl)ethyl)-1H- pyrazolo[3,4-d]pyrimidin-4(5H)- one | US10174037, Example 50
Type:
Small organic molecule
Emp. Form.:
C15H12F4N4O2
Mol. Mass.:
356.275
SMILES:
C[C@@H](c1ccc(cc1)C(F)(F)F)n1nc(CF)c2c1nc(O)[nH]c2=O |r|
Structure:
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