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Target
Cannabinoid receptor 1
Ligand
BDBM50459327
Substrate
n/a
Meas. Tech.
ChEMBL_1766243 (CHEMBL4201490)
EC50
1.9±n/a nM
Citation
 Liu, Y; Ji, L; Eno, M; Kudalkar, S; Li, AL; Schimpgen, M; Benchama, O; Morales, P; Xu, S; Hurst, D; Wu, S; Mohammad, KA; Wood, JT; Zvonok, N; Papahatjis, DP; Zhou, H; Honrao, C; Mackie, K; Reggio, P; Hohmann, AG; Marnett, LJ; Makriyannis, A; Nikas, SP ( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes. J Med Chem 61:8639-8657 (2018) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52856.55
Organism:
Rattus norvegicus (rat)
Description:
P20272
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50459327
Synonyms:
CHEMBL4213900
Type:
Small organic molecule
Emp. Form.:
C24H38N4O
Mol. Mass.:
398.5847
SMILES:
C[C@@H](\C=C/CCCCCN=[N+]=[N-])\C=C/C\C=C/C\C=C/CCCC(=O)NC1CC1 |r|
Structure:
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