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Target
Platelet-activating factor receptor
Ligand
BDBM50019677
Substrate
n/a
Meas. Tech.
ChEBML_158835
IC50
1200±n/a nM
Citation
 Tilley, JW; Burghardt, B; Burghardt, C; Mowles, TF; Leinweber, FJ; Klevans, L; Young, R; Hirkaler, G; Fahrenholtz, K; Zawoiski, S Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists. J Med Chem 31:466-72 (1988) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50019677
Synonyms:
2-Isopropyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid (1,1-dimethyl-4-pyridin-3-yl-butyl)-amide | CHEMBL301215
Type:
Small organic molecule
Emp. Form.:
C27H30N4O2
Mol. Mass.:
442.5527
SMILES:
CC(C)c1ccc2nc3ccc(cn3c(=O)c2c1)C(=O)NC(C)(C)CCCc1cccnc1
Structure:
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