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Target
Receptor-interacting serine/threonine-protein kinase 3
Ligand
BDBM50463030
Substrate
n/a
Meas. Tech.
ChEMBL_1777047 (CHEMBL4234039)
IC50
>10000±n/a nM
Citation
 Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition. Bioorg Med Chem 26:4209-4224 (2018) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 3
Synonyms:
RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3
Type:
PROTEIN
Mol. Mass.:
56886.12
Organism:
Human
Description:
ChEMBL_881455
Residue:
518
Sequence:
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
  
Inhibitor
Name:
BDBM50463030
Synonyms:
CHEMBL4239321
Type:
Small organic molecule
Emp. Form.:
C24H21N3O3
Mol. Mass.:
399.4418
SMILES:
CC(C)n1cc(C2=C(C(=O)N(O)C2=O)c2cn(C)c3ccccc23)c2ccccc12 |t:6|
Structure:
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