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Target
Sialidase A
Ligand
BDBM50467188
Substrate
n/a
Meas. Tech.
ChEMBL_1795335 (CHEMBL4267452)
IC50
1410000±n/a nM
Citation
 Chen, Z; Marcé, P; Resende, R; Alzari, PM; Frasch, AC; van den Elsen, JMH; Crennell, SJ; Watts, AG The synthesis and kinetic evaluation of aryl ?-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase. Eur J Med Chem 158:25-33 (2018) [PubMed]  Article 
Target
Name:
Sialidase A
Synonyms:
NANA_STREE | Neuraminidase A (NanA) | Sialidase A | nanA
Type:
Enzyme
Mol. Mass.:
114737.08
Organism:
Streptococcus pneumoniae
Description:
P62576; spr1536
Residue:
1035
Sequence:
MSYFRNRDIDIERNSMNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASEQPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLENVETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSSATKKDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTAELPKGRVRLYVNGVLSRTSLRSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTVYNRALTPEEVQKRSQLFKRSDLEKKLPEGAALTEKTDIFESGRNGKPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASDPSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYREGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGNQLLGNIYFTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRIIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWDFLSKDLISPTEAKVKRTREMGKGVIGLEFDSEVLVNKAPTLQLANGKTARFMTQYDTKTLLFTVDSEDMGQKVTGLAEGAIESMHNLPVSVAGTKLSNGMNGSEAAVHEVPEYTGPLGTSGEEPAPTVEKPEYTGPLGTSGEEPAPTVEKPEYTGPLGTAGEEAAPTVEKPEFTGGVNGTEPAVHEIAEYKGSDSLVTLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ
  
Inhibitor
Name:
BDBM50467188
Synonyms:
CHEMBL4295254
Type:
Small organic molecule
Emp. Form.:
C17H15N2O5P
Mol. Mass.:
358.2852
SMILES:
OP(O)(=O)C(Nc1cccc2ccccc12)c1ccc(cc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: