Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50467305
Substrate
n/a
Meas. Tech.
ChEMBL_1795780 (CHEMBL4267897)
Ki
135±n/a nM
Citation
 Rui, M; Rossino, G; Coniglio, S; Monteleone, S; Scuteri, A; Malacrida, A; Rossi, D; Catenacci, L; Sorrenti, M; Paolillo, M; Curti, D; Venturini, L; Schepmann, D; Wünsch, B; Liedl, KR; Cavaletti, G; Pace, V; Urban, E; Collina, S Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents. Eur J Med Chem 158:353-370 (2018) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50467305
Synonyms:
CHEMBL4294306
Type:
Small organic molecule
Emp. Form.:
C28H32ClNO
Mol. Mass.:
434.013
SMILES:
Cl.O=C(CCCN1CCC(Cc2ccccc2)CC1)c1ccc(cc1)-c1ccccc1
Structure:
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