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Target
Cyclin-dependent kinase 2
Ligand
BDBM50468264
Substrate
n/a
Meas. Tech.
ChEMBL_1799038 (CHEMBL4271330)
IC50
1.000000±n/a nM
Citation
 Kalra, S; Joshi, G; Munshi, A; Kumar, R Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors. Eur J Med Chem 142:424-458 (2017) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50468264
Synonyms:
CHEMBL4292930
Type:
Small organic molecule
Emp. Form.:
C20H26N6O2
Mol. Mass.:
382.4594
SMILES:
Cc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@@H]1CCO |r|
Structure:
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