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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1/2
Ligand
BDBM50470260
Substrate
n/a
Meas. Tech.
ChEMBL_204599 (CHEMBL813361)
IC50
9.1±n/a nM
Citation
 Kumazawa, T; Takami, H; Kishibayashi, N; Ishii, A; Nagahara, Y; Hirayama, N; Obase, H (E)-4-(2-[[3-(indol-5-yl)-1-oxo-2-butenyl]amino]phenoxy)butyric acid derivatives: a new class of steroid 5 alpha-reductase inhibitors in the rat prostate. 1. J Med Chem 38:2887-92 (1995) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1/2
Synonyms:
Steroid 5-alpha-reductase
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 204723
Components:
This complex has 2 components.
Component 1
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
S5A1_RAT | Srd5a1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
PROTEIN
Mol. Mass.:
29788.29
Organism:
Rattus norvegicus
Description:
ChEMBL_1441437
Residue:
259
Sequence:
MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQELPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLAFLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGETGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWYHEKFEDYPKSRKILIPFVL
  
Component 2
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
S5A2_RAT | Srd5a2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2
Type:
PROTEIN
Mol. Mass.:
28784.15
Organism:
Rattus norvegicus
Description:
ChEMBL_205054
Residue:
254
Sequence:
MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPSFVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCIGNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRIPRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFKDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50470260
Synonyms:
CHEMBL99860
Type:
Small organic molecule
Emp. Form.:
C32H34N2O4
Mol. Mass.:
510.6234
SMILES:
CCCC(c1ccccc1)n1ccc2cc(ccc12)C(\C)=C\C(=O)Nc1ccccc1OCCCC(O)=O
Structure:
Search PDB for entries with ligand similarity: