Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50475476
Substrate
n/a
Meas. Tech.
ChEMBL_321083 (CHEMBL872163)
Ki
7.9±n/a nM
Citation
 Ahmed, MBriggs, MABromidge, SMBuck, TCampbell, LDeeks, NJGarner, AGordon, LHamprecht, DWHolland, VJohnson, CNMedhurst, ADMitchell, DJMoss, SFPowles, JSeal, JTStean, TOStemp, GThompson, MTrail, BUpton, NWinborn, KWitty, DR Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists. Bioorg Med Chem Lett 15:4867-71 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50475476
Synonyms:
CHEMBL196103
Type:
Small organic molecule
Emp. Form.:
C22H20ClN3O2S
Mol. Mass.:
425.931
SMILES:
Clc1ccc2n(ccc2c1N1CCNCC1)S(=O)(=O)c1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: