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Target
Reverse transcriptase
Ligand
BDBM50477199
Substrate
n/a
Meas. Tech.
ChEMBL_450288 (CHEMBL900569)
Ki
20±n/a nM
Citation
 Mai, A; Artico, M; Rotili, D; Tarantino, D; Clotet-Codina, I; Armand-Ugón, M; Ragno, R; Simeoni, S; Sbardella, G; Nawrozkij, MB; Samuele, A; Maga, G; Esté, JA Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains. J Med Chem 50:5412-24 (2007) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50477199
Synonyms:
CHEMBL239342
Type:
Small organic molecule
Emp. Form.:
C18H21F2N3O
Mol. Mass.:
333.3756
SMILES:
CC(c1nc([nH]c(=O)c1C)N1CCCCC1)c1c(F)cccc1F
Structure:
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