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Target
Geranylgeranyl transferase type-1 subunit beta
Ligand
BDBM50481908
Substrate
n/a
Meas. Tech.
ChEMBL_622367 (CHEMBL1100174)
IC50
98000±n/a nM
Citation
 Tan, KT; Guiu-Rozas, E; Bon, RS; Guo, Z; Delon, C; Wetzel, S; Arndt, S; Alexandrov, K; Waldmann, H; Goody, RS; Wu, YW; Blankenfeldt, W Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors. J Med Chem 52:8025-37 (2009) [PubMed]  Article 
Target
Name:
Geranylgeranyl transferase type-1 subunit beta
Synonyms:
GGTase-I-beta | Geranylgeranyl transferase type I subunit beta | Geranylgeranyl transferase type-1 subunit beta | PGTB1_RAT | Pggt1b | Type I protein geranyl-geranyltransferase subunit beta | geranylgeranyltransferase type-I
Type:
PROTEIN
Mol. Mass.:
42414.77
Organism:
Rattus norvegicus
Description:
ChEMBL_105008
Residue:
377
Sequence:
MAATEDDRLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHISS
  
Inhibitor
Name:
BDBM50481908
Synonyms:
CHEMBL1075861
Type:
Small organic molecule
Emp. Form.:
C40H53N7O4
Mol. Mass.:
695.8933
SMILES:
CCCCCCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CN(C)CCc1ccccn1)Cc1ccc(O)cc1 |r|
Structure:
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