Reaction Details
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Presenilin-1
Ligand
BDBM50485974
Substrate
n/a
Meas. Tech.
ChEMBL_872382 (CHEMBL2188244)
IC50
37±n/a nM
Citation
Huang, X; Zhou, W; Liu, X; Li, H; Sun, G; Mandal, M; Vicarel, M; Zhu, X; Bennett, C; McCraken, T; Pissarnitski, D; Zhao, Z; Cole, D; Gallo, G; Zhu, Z; Palani, A; Aslanian, R; Clader, J; Czarniecki, M; Greenlee, W; Burnett, D; Cohen-Williams, M; Hyde, L; Song, L; Zhang, L; Chu, I; Buevich, A Synthesis and SAR Studies of Fused Oxadiazines as ?-Secretase Modulators for Treatment of Alzheimer's Disease. ACS Med Chem Lett 3:931-5 (2012) [PubMed] Article More Info.:
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
Inhibitor
Name:
BDBM50485974
Synonyms:
CHEMBL2180376
Type:
Small organic molecule
Emp. Form.:
C25H25FN4O2
Mol. Mass.:
432.49
SMILES:
COc1cc(\C=C2/CCCN3[C@H](CON=C23)c2ccc(F)cc2)ccc1-n1cnc(C)c1 |r,t:14|
Structure:
